In this week’s Neurology, Parra et al. present a compelling appeal and thoughtful plan for addressing the devastating and growing burden of dementia in Latin America. This report, which has its early roots in a meeting of experts in Santiago during the World Congress of Neurology in 2015, identifies the key challenges and maps a way forward with a public health approach that emphasizes optimizing affordable diagnostics and care over biomarker research given the opportunity cost of such activities. Challenges are identified in the limited epidemiological insights available for Latin America and the dearth of clinical experts in dementia. They identify a need to focus new training programs on front line healthcare workers and to mobilize existing experts to leverage political will to address the rapidly growing burden of dementia in the region. Lessons learned and successful actions taken in Latin American could be important for informing the growing global burden of dementia countries across the economic spectrum.